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English to Spanish: The roles of sodium-glucose cotransporter 2 inhibitors in preventing kidney injury in diabetes General field: Medical
Source text - English Diabetic nephropathy (DN) is the leading cause of end stage renal disease (ESRD) worldwide. The early effective treatment of high plasma glucose could delay or prevent the onset of DN. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are new target treatments for ameliorating high plasma glucose and help to maintain glucose homeostasis in diabetic patients. Reduced renal glucose reabsorption by SGLT2 inhibition seems to have high potential to improve glycemic control in diabetes mellitus (DM) not only through glucose lowering but also through glucose-independent effects such as blood pressure-lowering and direct renal effects in diabetes. Of note, the important events in the pathogenesis of glucose-induced renal injury and DN including oxidative stress, inflammation, fibrosis and apoptosis conditions have shown to be ameliorate after the treatment with SGLT2 inhibitors. Interestingly, SGLT2 inhibitors have been reported to reduce albuminuria in DM via an activation of renal tubuloglomerular feedback by increased macula densa sodium and chloride delivery, leading to afferent vasoconstriction and attenuated diabetes-induced renal hyperfiltration. These effects also help to conserve glomerular
integrity. Thus, the treatment of diabetes mellitus using SGLT2 inhibitors could be one of the effective approach for the management of diabetic-associated kidney disease like DN. This review summarizes the up to date information and discusses the bidirectional relationship between the SGLT2 inhibitor treatments and the renal functions that are available from both basic research and clinical reports. The details of renal outcomes of SGLT2 inhibitors in DN are also provide in this review.
Translation - Spanish La nefropatía diabética (ND) es la causa principal de las enfermedades renales en etapa terminal (ERET) a nivel mundial. El tratamiento temprano y eficaz del alto nivel de glucosa en plasma podría retrasar o prevenir la aparición de la ND. Los inhibidores del cotransportador de sodio-glucosa tipo 2 (SGLT2) son los nuevos tratamientos específicos con el objetivo de mejorar los altos niveles de glucosa en plasma y ayudar a mantener la homeostasis de la glucosa en pacientes diabéticos. La reducción de la reabsorción renal de glucosa gracias a la inhibición del SGLT2 parece tener un gran potencial para mejorar el control glucémico en la diabetes mellitus (DM) no solo mediante la reducción de la glucosa sino que también mediante efectos independientes de la glucosa como la disminución de la presión arterial y los efectos renales directos en la diabetes. Cabe señalar que los eventos importantes en la patogénesis de la insuficiencia renal inducida por glucosa y la ND, incluyendo condiciones del estrés oxidativo, la inflamación, la fibrosis y la apoptosis, han demostrado una mejoría después del tratamiento con inhibidores del SGLT2. Curiosamente, se ha reportado que los inhibidores del SGLT2 reducen la albuminuria en la DM mediante una activación de la retroalimentación tubuloglomerular renal gracias al aumento en la administración de sodio y cloruro a la mácula densa, lo que conlleva una vasoconstricción aferente y una atenuación de la hiperfiltración renal inducida por la diabetes. Estos efectos también ayudan a conservar la integridad glomerular. De este modo, el tratamiento de la diabetes mellitus con el uso de inhibidores del SGLT2 podría ser uno de los métodos efectivos para controlar enfermedades renales asociadas con la diabetes como la ND. Esta revisión sintetiza la información existente hasta la fecha y discute la relación bidireccional entre los tratamientos con inhibidores del SGLT2 y las funciones renales que están disponibles tanto en investigaciones básicas como en informes clínicos. En esta revisión también se ofrecen los detalles de los resultados renales de los inhibidores del SGLT2 en la ND.
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Bachelor's degree - UPLA
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Years of experience: 9. Registered at ProZ.com: Feb 2018.
Hello, I am a freelance translator and interpreter.
I've got a degree in English-Spanish Translation and Interpreting.
I specialize on the translation and localization of literature (including novels, poetry and plays), publicity, pharmacology, general medicine, ITs, software and video games.
I have worked on the translation of two published books, I have also worked for translation agencies as well as private clients and as an interpreter in the areas of astronomy and tourism.
I'm a diligent translator who is always ready to learn something new and prides himself on achieving the best quality translations before the deadline is met, no matter what.
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